EFFECTS OF AQUEOUS EXTRACT OF GARCINIA KOLA SEEDS ON THE HISTOMORPHOLOGY OF THE BONE MARROW AND PERIPERAL BLOOD COUNT OF CHLORAMPHENICOL-INDUCED ANEMIA IN ADULT WISTAR RATS

ABSTRACT

In this study, the effects of Garcinia kola seeds on the histomorphology of the bone marrow and peripheral blood count (haematological parameters) of chloramphenicol-induced anemia in Wistar rats were investigated. Thirty-six adult wistar rats were assigned into group A, B, C, D, E & F. Each group consisting of six animals.

Group A rats had normal feed and water ad libitum. Group B rats had 50mg/kg of chloramphenicol only. Group C rats had 50mg/kg of chloramphenicol and 400mg/kg of Garcinia kola extract concurrently. Group D had 50mg/kg of chloramphenicol and 800mg/kg of Garcinia kola extract concurrently. Group E had 400mg/kg of G.kola extract only while Group F had 800mg/kg of G. Kola extract only. The period of administration was 14 days. Histological and haematological findings indicated that aqueous seed extract of Garcinia kola at a higher dose of 800 mg/kg body weight over a period of 14 days, showed markedly increased myleoid-erythroid cell populations, presence of megakaryocytes in the bone marrow and statistical significances(p < 0.05) for erythrocyte count, haematocrit and haemoglobin concentration. The elicitation of these effects by the plant seems to be a reflection of its traditionally believed blood boosting effect and antioxidative properties.